Melatonin users have 90% higher chance of developing heart failure, twice as likely to die: New study

Melatonin Users May Face Higher Heart Risk

A recent study suggests that adults with insomnia who take melatonin for extended periods may face a significantly elevated risk of heart failure. Researchers found that those using the supplement long-term had a 90% greater chance of developing heart failure compared to non-users.

Key Findings

Adults taking melatonin for at least one year had a much higher likelihood of heart failure.
They were also more likely to be hospitalized or die from any cause within five years.
The study analyzed health records of over 130,000 adults with insomnia and no prior heart failure history.
In the United Kingdom, where melatonin is prescription-only, individuals with repeat prescriptions showed an 82% higher risk.
Those taking melatonin long-term were nearly 3.5 times more likely to be hospitalized for heart failure than nonusers.

Study Context

The findings were presented at the American Heart Association (AHA) Scientific Sessions 2025. Melatonin remains one of the most widely used over-the-counter sleep aids in the United States, with almost six million Americans relying on it for better sleep. Despite its popularity, the study raises questions about potential cardiovascular risks linked to chronic use.

“Long-term use of melatonin may carry serious risks for adults suffering from insomnia,” researchers warned.

Author’s Summary

New research warns frequent, long-term melatonin users could face nearly double the risk of heart failure and significantly higher hospitalization rates.

Mint — 2025-11-08

Melatonin Users May Face Higher Heart Risk

Key Findings

Study Context

Author’s Summary

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