Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

New research indicates that individuals with insomnia who take melatonin supplements for over a year may face an increased risk of heart failure compared to those who do not use this common sleep aid.

Key Findings of the Study

Long-term melatonin use is associated with a higher likelihood of being diagnosed with heart failure.
Users of melatonin supplements for more than one year are more prone to hospitalization due to heart failure.
There is also a greater risk of death from any cause among long-term melatonin users.

Research Context and Presentation

The findings are based on a preliminary study that will be presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans. The study has not yet been published in a peer-reviewed journal.

Limitations and Cautions

The researchers emphasized that their study does not prove a direct cause-and-effect link between melatonin use and heart failure. However, they warned that these results raise concerns about the safety of prolonged melatonin consumption and call for additional research to evaluate its cardiovascular effects.

Concerns Over Supplement Regulation

Many melatonin supplements are available over-the-counter without a prescription, and they are not regulated. This allows people to use them without medical supervision, which may increase risks.

“Melatonin supplements may not be as harmless as commonly assumed.”

Author’s summary: Long-term use of melatonin supplements could pose significant heart health risks, highlighting the need for further investigation and cautious use under medical guidance.

Healthline — 2025-11-05