Broad Survival Benefit from MATTERHORN Trial Highlights New Approach to Biomarker Use | Applied Clinical Trials Online

Broad Survival Benefit from MATTERHORN Trial

The MATTERHORN trial's results show a new approach to biomarker use, potentially expanding access to immunotherapy in early gastric and GEJ cancer treatment.

Nancy Ghattas, VP, US Oncology Commercial Franchise Head of Immuno-Oncology at AstraZeneca, discussed the trial's significance in a video interview.

The Imfinzi-based perioperative regimen demonstrated a 22% reduction in the risk of death and improved overall survival regardless of PD-L1 status.

This marks the first immunotherapy in this setting to show such benefit, reshaping biomarker strategies.

Author's summary: MATTERHORN trial expands immunotherapy access.

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Applied Clinical Trials Online Applied Clinical Trials Online — 2025-10-30

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