The MATTERHORN trial's results show a new approach to biomarker use, potentially expanding access to immunotherapy in early gastric and GEJ cancer treatment.
Nancy Ghattas, VP, US Oncology Commercial Franchise Head of Immuno-Oncology at AstraZeneca, discussed the trial's significance in a video interview.
The Imfinzi-based perioperative regimen demonstrated a 22% reduction in the risk of death and improved overall survival regardless of PD-L1 status.
This marks the first immunotherapy in this setting to show such benefit, reshaping biomarker strategies.
Author's summary: MATTERHORN trial expands immunotherapy access.